Fillers, like Juvederm, Restylane, and Beltero are made from hyaluronic acid, a naturally occurring substance in the body. Filler is injected directly into problem areas to smooth-out folds and wrinkles, add volume to the lips, add contour to facial features that have lost their fullness. Common areas where filler is used include lips, nasolabial folds (laugh lines near mouth and nose), marionette lines (lines extending from the corners of the mouth), tear troughs (under eye area), midface (cheeks/cheekbones). Results from fillers last 6-12+ months, with some formulations lasting up to 2 years.